Tumor-informed liquid biopsy detection of structural variants in high grade serous ovarian cancer (IMAGE)
Caption
Quantification of tumor-informed SVs of HGSOCs in liquid biopsy.
( A–D) Concentrations (copy numbers per ng sample input) of targeted SVs were measured by ddPCR (digital droplet PCR). Each column represents the mean value of 1 or 2 replicates due to sample limitations. Germline control WBC(white blood cell) and subject pre-treatment cfDNA (cell-free DNA) of each HGSOC, pooled healthy cfDNA and a NTC were used for all experiments. (A) In HGSOC#1, 4 SV targets (SV1, 3, 4, 5) were measured. (B) In HGSOC#2, 3 SV targets (SV1, 4, 6) were measured. (C) In HGSOC#3, subject post-surgery cfDNA was also used in ddPCR and 4 SV targets (SV1, 3, 4, 8) were measured. (D) In HGSOC#4, 4 SV targets (SV1, 2, 3, 5) were measured.
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Copyright: © 2026 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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