Figure 1: Tryptophan-rich allosteric communication network in a GPCR (IMAGE)

Institute of Science Tokyo

Figure 1: Tryptophan-rich allosteric communication network in a GPCR

Caption

Computational analysis using rigidity-theory indicates that activation of the human adenosine A2A receptor (shown here) is regulated by long-range allosteric communication pathways (highlighted in red and other bright colors). Many tryptophan residues (shown as sticks) lie along these pathways, supporting their role as key nodes in the allosteric network that controls GPCR activation and functional state regulation.

Credit

Kitao et al., 2025, Proceedings of the National Academy of Sciences (PNAS)

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