Overview of the inflammatory feedback mechanism discovered in TCF3::HLF-positive B cell acute lymphoblastic leukemia (IMAGE)

Tokyo University of Science

Overview of the inflammatory feedback mechanism discovered in TCF3::HLF-positive B cell acute lymphoblastic leukemia

Caption

As depicted in the image, a newly found regulatory region in the genome leads to increased IL-1β production, leading to a self-sustaining loop. This excess IL-1β also drives the activation of osteoclasts, which ultimately causes bone damage.

Credit

Professor Tomokatsu Ikawa from Tokyo University of Science, Japan

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