CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer (IMAGE)
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Figure 2:
Relative gene expression of AR, FOLH1 (PSMA), KLK2, and KLK3 (PSA) are shown across the top (high) and bottom (low) quartiles of CREB5 expression in (A) CRPC (SU2C, n = 104) and (B) primary PC tumors (TCGA, n = 493). (C) In the same CRPC cohort, we compared AR-V7 expression levels in tumors with high and low CREB5 expression. (D, E) Using stacked bar graphs, we further compared the percent of tumors with various types of somatic alterations in CRPC and primary PC tumors with high and low CREB5 expression. Differences in alteration frequencies were evaluated using Fisher’s exact test (*p < 0.05, **p < 0.01, **p < 0.001, **p < 0.0001, and ns = non-significant).
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Copyright: © 2026 Makovec et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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