Aromatase in adipose tissue regulates bone mass via phosphate metabolism in the kidney (IMAGE)

Ehime University

Aromatase in adipose tissue regulates bone mass via phosphate metabolism in the kidney

Caption

In AroΔaP2 mice, E2 biosynthesis by aromatase in adipose tissue was suppressed, resulting in suppression of fat-derived novel factor (s) that regulates renal NaPi2 protein levels, suppressing renal phosphate reabsorption and reducing serum phosphate levels. As a result, AroΔaP2 mice exhibited an abnormal bone calcification phenotype.

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Aoi Ikedo and Yuuki Imai

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