E3 ubiquitin ligase MIEL1 inhibits auto-ubiquitination and self-degradation of XBAT31 to promote thermo-responsive growth via ELF3-PIF4 pathway (IMAGE)
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Under mild high-temperature conditions, MIEL1 in wild-type plants interacts with XBAT31, obstructing XBAT31 self-interaction. This maintains XBAT31 protein stability, allowing XBAT31 to mediate the ubiquitination and degradation of ELF3. The reduction in ELF3 protein levels alleviates its inhibition on PIF4 transcriptional activity, promoting the expression of heat-responsive genes and hypocotyl elongation. In contrast, in the MIEL1 mutant, the absence of MIEL1 protein leads to XBAT31 self-interaction, triggering auto-ubiquitination and degradation. Consequently, ELF3 protein accumulates, inhibiting PIF4's transcriptional activity, reducing the expression of heat-responsive genes, and suppressing hypocotyl elongation.
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