Specific Patterns of CD39 Expression on T-cells of HIV/HCV Coinfected Patients Receiving Antiretroviral Therapy (IMAGE)
Caption
We have demonstrated that CD4+ T-cells, namely their CD45RA+ subset, act as the main regulators of purinergic signals in HIV/HCV coinfected and healthy individuals. At the same time, the proportion of CD4+ T-cells involved in the control of purinergic signaling was increased in HIV/HCV coinfected patients compared with healthy subjects. These CD39-positive T-cells circulated between lymphoid organs and migrated to inflamed sites in response to increased concentrations of pro-inflammatory cytokines and chemokines.
Credit
Evgeniya Saidakova
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