Study sheds light on how to lengthen the effects of antidepressant drugs (IMAGE)
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A major drawback of ketamine when used as an antidepressant is that depressive symptoms often reappear within a few weeks. In this study, researchers found that NOX-1 inhibition could extend the antidepressant effects of ketamine. Moreover, a newly developed compound, called K-4, exhibited sustained antidepressant effects by acting as a positive modulator of AMPA receptors.
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Professor Takuya Takahashi from Yokohama City University Graduate School of Medicine, Japan
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