Molecular classification system of intrahepatic cholangiocarcinoma (iCCA) (IMAGE)

BGI Genomics

Molecular classification system of intrahepatic cholangiocarcinoma (iCCA)

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To address this challenge, the team identified a low-intratumor heterogeneity/high-intertumor variability (LIHV) gene set. This 1,341-gene signature focuses on markers that remain stable within an individual’s tumor but vary significantly between patients. By filtering out inconsistent "noise", the LIHV framework enables a more robust and reproducible classification of iCCA into five molecular subtypes, each associated with distinct therapeutic vulnerabilities:

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BGI Genomics & Zhongshan Hospital of Fudan University

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