Lung cancer and LNPs (IMAGE)

Oregon State University

Lung cancer and LNPs

Caption

Lipid nanoparticles consisting of DC-cholesterol and 113-O12B ionizable lipid bind with vitronectin (Vtn) in blood, forming a protein corona that enables interaction with vitronectin receptors. These receptors are abundant in lung tissues and overexpressed in tumor microenvironments. The nanoparticles demonstrate preferential accumulation in lung tumors compared to surrounding lung tissue, making them effective for targeted mRNA delivery to lung cancer. This cancer-preferential mRNA delivery achieved approximately 2.5-fold greater reduction in tumor burden than liver-tropic LNPs producing systemic FST. Furthermore, it efficiently mitigated cancer cachexia by improving food intake, maintaining body weight, and preserving muscle and adipose tissues without adverse effects.
 

Credit

Graphic by Parinaz Ghanbari.

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