BRD2 and BRD4: Same Family, Different Jobs (IMAGE)

Max Planck Institute of Immunobiology and Epigenetics

BRD2 and BRD4: Same Family, Different Jobs

Caption

Super-resolution microscopy images of cell nuclei showing BRD2 (green) and BRD4 (red) inside the nucleus. When transcription elongation is blocked with flavopiridol (right), BRD2 clusters increase markedly while BRD4 distribution shifts — visually demonstrating that the two proteins respond differently to the same perturbation, reflecting their distinct roles in initiating (BRD2) versus driving gene transcription (BRD4).

Credit

MPI of Immunobiology & Epigenetics, Asifa Akhtar

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