TMPRSS2-G4 (Pu23m3) interaction with berberine (IMAGE)

Chinese Journal of Natural Medicines

TMPRSS2-G4 (Pu23m3) interaction with berberine

Caption

 (A) Coptis chinensis Franch. is rich in berberine, and the surface view of the BER-TMPRSS2-G4 complex structure is shown. (B) 1D 1H NMR spectra displaying imino region changes of TMPRSS2-G4 upon titration with berberine. The top spectrum corresponds to the 35 °C, 3∶1 BER-TMPRSS2-G4 complex. (C) Representative 2D NOESY spectra of the 3∶1 BER-TMPRSS2-G4 complex show intermolecular cross-peaks between berberine and TMPRSS2-G4 at 35 °C. Conditions: 1.93 mmol·L−1 DNA, 350 ms mixing time, 10 mmol·L−1 K+ solution, pH 7.0.

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Chinese Journal of Natural Medicines

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