Distinct Kinesin-2 Assemblies Drive Selective Protein Transport in Neurons (IMAGE)

Juntendo University Research Promotion Center

Distinct Kinesin-2 Assemblies Drive Selective Protein Transport in Neurons

Caption

Kinesin-2 motor proteins transport cargo along neuronal microtubules to ensure proper cellular organization. This study shows that kinesin-2 exists as distinct assemblies with different compositions and cargo-binding properties. A KIF3B-enriched assembly preferentially transports TRIM46, an axon-organizing protein, to the axon initial segment, highlighting how motor diversity enables selective protein delivery in neurons.

Credit

Professor Nobutaka Hirokawa from the Graduate School of Medicine, Juntendo University, Tokyo, Japan

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