Recently, the Insilico team’s research entitled “An Internal Sulfur-Lone Pair Interaction Enabled the Discovery of Potential and Sub-Family Selective PKMYT1 Inhibitors” was invited for publication as a cover Feature in ChemMedChem (IMAGE)

InSilico Medicine

Recently, the Insilico team’s research entitled “An Internal Sulfur-Lone Pair Interaction Enabled the Discovery of Potential and Sub-Family Selective PKMYT1 Inhibitors” was invited for publication as a cover Feature in ChemMedChem

Caption

The core innovation of this work lies in the clever exploitation of noncovalent interactions. Through a conformational restriction strategy, the molecular spatial geometry is precisely controlled while hydrogen‑bond donors that could adversely affect physicochemical properties are effectively masked.

Credit

Insilico Medicine & ChemMedChem

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Public Domain

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