Expanding role of FAK in tumor progression and emerging therapeutic strategies (IMAGE)

Science China Press

Expanding role of FAK in tumor progression and emerging therapeutic strategies

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Graphical illustration depicting the multifaceted role of FAK in cancer. FAK is activated by integrins, RTKs, and GPCRs, driving downstream oncogenic processes including proliferation, EMT/invasion, metastasis, cancer stemness, and chemoresistance. FAK also modulates the tumor microenvironment by regulating endothelial cells, CAFs, macrophages, MDSCs, NK cells, T cells, and dendritic cells, impacting vascularization, TME remodeling, and immune evasion. Emerging FAK-targeted therapeutic strategies include kinase inhibitors, combination therapies, PROTAC degraders, PPI blockers, and natural compounds.

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