P2X7 Receptor–Mediated Colonic Motility Mechanism Driving Defecation-Inducing Strong Contractions by ATP (IMAGE)

Saitama University

P2X7 Receptor–Mediated Colonic Motility Mechanism Driving Defecation-Inducing Strong Contractions by ATP

Caption

RESEARCHERS UTILIZE SUNCUS MURINUS AS A MODEL ANIMAL FOR HUMAN GASTROINTESTINAL MOTILITY, DEMONSTRATING THAT ATP RELEASED FROM PURINERGIC NEURONS ACTIVATES P2X7 RECEPTORS, COORDINATING WITH CHOLINERGIC AND SEROTONERGIC/ADRENERGIC NEURONS TO REGULATE GIANT MIGRATING CONTRACTIONS (GMC), THEREBY CONTROLLING DEFECATION BEHAVIOR.

Credit

Ichiro Sakata from Saitama University

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