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Institute for Basic Science

Figure 1

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Synthetic Trogocytosis (SynTrogo) enables the "nibbling" of neuronal membranes by astrocytes through engineered ligand and receptor proteins. Upon SynTrogo induction, the synaptic density of the target CA3-CA1 hippocampal circuit was significantly reduced by ~27%. Conversely, the remaining synapses underwent structural and functional remodeling – characterized by the enlargement of pre- and post-synaptic compartments, enhanced long-term potentiation (LTP), and improved memory formation and retention.

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Institute for Basic Science

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