Treg surface molecules and secreted mediators involved in tumourigenesis and immunosuppression. (IMAGE)

First Hospital of Jilin University

Treg surface molecules and secreted mediators involved in tumourigenesis and immunosuppression.

Caption

ATP, adenosine triphosphate; CCL, chemokine (C-C motif) ligand 2; CCR, C-C motif chemokine receptor; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; DC, dendritic cell; FoxP3, forkhead box P3; eTreg, effector Treg; HSC, hepatic stellate cell; ICOS, inducible costimulatory; ICOSL, ICOS ligand; IL, interleukin; iTreg, induced Treg; LAG3, lymphocyte activating 3; LSEC, liver sinusoidal endothelial cells; MHC, major histocompatibility complex; NETs, neutrophil extracellular traps; neu, neutrophil; NK, natural killer; nTreg, natural Treg; PD-1, programmed cell death-protein 1; TCR, T cell receptor; Teff, effector T cell; TGF-β, transforming growth factor-beta; Treg, regulatory T cell.

Credit

By Grace Wu, Hai Huang, et al.

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License

CC BY-NC

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