Schematic illustration of the PfPI3K-mediated inhibition of PS externalization on iRBCs (IMAGE)
Caption
PfPI3K stabilizes the mitochondrial membrane and regulates Ca2. It also phosphorylates PfPLSCR1, leading to PS internalization inside the iRBC plasma membrane. When PfPI3K is inhibited, 14–3–3 modification is disrupted, increasing mitochondrial membrane permeability and Ca2+ release. Dephosphorylation of PfPLSCR1 enhances PS externalization and recognition by M2 macrophages.
Credit
Prof. Qijun Chen from the Shenyang Agricultural University, Shenyang, China Image source link: https://link.springer.com/article/10.1007/s44466-026-00036-2/figures/6
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