Obesity promotes breast cancer metastasis (IMAGE)
Caption
: (A) The HFD-induced MMTV-PyMT mouse model. (B) Body weight changes in HFD-induced MMTV-PyMT mice (n = 6 for each group). (C) Obesity increases the weight of primary mammary tumors and the number of lung metastases of MMTV-PyMT mice. (D–F) Representative microscopic images of lung tissues (D), relative mRNA levels (normalized to Gapdh) of the EMT-related genes and Ctgf gene in the 4th pair of mammary tumors (E) and metastatic lung tissues (F) of MMTV-PyMT mice (n = 6) fed with a HFD. (G) Model of the HFD-induced 4T1 breast intra-tumoral model. (H) Body weight changes in the HFD-induced 4T1 breast intra-tumoral model (n = 6 for each group). (I) Obesity increases primary tumor weight and the number of metastases in lung and liver tissues after the inoculation of 4T1 cells in mice. (J–M) Representative microscopic images of lung tissues (J), relative mRNA levels (normalized to Gapdh) of the EMT-related genes and Ctgf gene in the primary tumors (K), lung tissues (L), and liver tissues (M) of the 4T1 tumor-bearing mice (n = 6) fed with a high-fat diet. The data were presented as mean ± standard deviation. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. n.s., no significance.
Credit
Saijun Wang, Mingwei Guo, Lingyun Xu, Jiaming Xue, Shuai Chen, Ke Xu, Yan Zhou, Aihua Gu, Wei Gao, Jianwei Zhou, Yi Zhang, Liming Tang, Dongmei Wang
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