Insulin Resistance and Leptin Dysregulation Impact In Vivo Brain Structure and Cognitive Functioning in Mood Disorders: A Multimodal Partial Least Squares Path Modeling Study (IMAGE)

Elsevier

Insulin Resistance and Leptin Dysregulation Impact In Vivo Brain Structure and Cognitive Functioning in Mood Disorders: A Multimodal Partial Least Squares Path Modeling Study

Caption

Graphical representation of how metabolism, brain structure (gray matter volume, GMV), and cognitive abilities are significantly related in the bipolar disorder group. (A) The main diagram shows how these three domains are connected: thicker lines indicate stronger and more reliable relationships. The side panels highlight the biological markers that contribute most strongly to metabolism (B), the cognitive domains that weigh most on overall cognitive performance (C), and the brain regions that contribute most to gray matter volume (top 20) (D).

Credit

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging / Raffaelli et al.

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