Fig. 1 (IMAGE)
Caption
Overview of the study.
Left: In wild-type cells, RLF/ZFP292 support the proper function of the CoREST complex, leading to the removal of active histone marks and preventing excessive expression of differentiation-associated genes.
Right: In the absence of RLF/ZFP292, CoREST complex function is impaired, resulting in an increase in active histone marks and elevated expression of differentiation-associated genes. Consequently, the undifferentiated state cannot be maintained, and cells undergo differentiation.
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The University of Osaka
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