Genetic Susceptibility to Schizophrenia and the Onset of Brain Developmental Change in Adolescence (IMAGE)

Elsevier

Genetic Susceptibility to Schizophrenia and the Onset of Brain Developmental Change in Adolescence

Caption

A study in Biological Psychiatry has found that genetic risk of schizophrenia manifests in early adolescence, showing that structural brain changes can be detected years before symptoms appear in young adulthood. The findings provide critical insights for refining developmental models of schizophrenia, and for informing the timing of preventive interventions. This image details the dynamic neurodevelopmental changes identified in the study. A: Brain areas significantly associated with genetic susceptibility to schizophrenia; B & C: Developmental trajectories in these regions differ depending on genetic susceptibility; D: Longitudinal trajectories of brain changes in these regions for individuals with high vs. low genetic liability.

Credit

Biological Psychiatry / Xu et al.)

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CC BY

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