Long-Read Whole-Transcriptome Sequencing and Selective Gene Panel Profiling Enable Sensitive Detection of Fusion Oncogenes in Pediatric B-Cell Acute Lymphoblastic Leukemia (IMAGE)
Caption
Comparison of conventional B-cell acute lymphoblastic leukemia (B-ALL) fusion diagnostics (top) and Nanopore-based fusion detection (bottom). Current diagnostics involve multiple tests, whereas next-generation sequencing methods, such as Oxford Nanopore Technologies whole-transcriptome sequencing (ONT-WTS), may reduce complexity and the number of different assays. FUSILLI offers a potential method for direct detection of B-ALL fusions from ONT-WTS. CBC, complete blood cell count; Diff, differential; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry.
Credit
The Journal of Molecular Diagnostics / Lin et al.
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