Schematic illustration of the fabrication of PFB@CM nanomotors and their near-infrared (NIR)-activated multimodal antitumor mechanisms involving photothermal, chemodynamic, and nitric oxide (NO)-mediated synergistic therapy. (IMAGE)

Beijing Institute of Technology Press Co., Ltd

Schematic illustration of the fabrication of PFB@CM nanomotors and their near-infrared (NIR)-activated multimodal antitumor mechanisms involving photothermal, chemodynamic, and nitric oxide (NO)-mediated synergistic therapy.

Caption

Polydopamine-Fe/BNN6 (PFB) nanoparticles were synthesized and camouflaged with cancer cell membranes to form PFB@CM nanomotors, thereby improving biocompatibility and tumor targeting. Under NIR irradiation, the PFB@CM nanomotors generated a strong photothermal response that drove 3 synergistic processes: self-thermophoretic propulsion to enhance cellular uptake, NO release via heat-triggered BNN6 decomposition, and accelerated Fe(II) liberation from the polydopamine (PDA) matrix. The released Fe(II) converts endogenous H2O2 into ·OH via a Fenton-like reaction, and ·OH further reacts with NO to yield cytotoxic ONOO−.

Credit

Chengzhi Hu, Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology.

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