Schematic diagram illustrating the effects of fexaramine (Fex) on metabolic and reproductive functions in PCOS-like mice. (IMAGE)

Shanghai Jiao Tong University Journal Center

Schematic diagram illustrating the effects of fexaramine (Fex) on metabolic and reproductive functions in PCOS-like mice.

Caption

The gut-restricted FXR agonist Fex effectively improved both metabolic and reproductive phenotypes in mouse models of PCOSS. AMH: anti-Müllerian hormone; GTT: glucose tolerance test; ITT: insulin tolerance test; LH: luteinizing hormone; PCOS: polycystic ovary syndrome.

Credit

Wang, Yang; Zhang, Chu-Jun; Yang, Jia-Qi; Wang, Yu-Hui; Kang, An-Hui; Liu, Xi-Tong; Liu, Yan; Cai, Qing-Qing; Li, Xin; Zhang, Fei-Fei; Xu, Cong-Jian.

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