Open micro-valley chip for viscosity-driven glioblastoma invasion study. (IMAGE)

Aerospace Information Research Institute, Chinese Academy of Sciences

Open micro-valley chip for viscosity-driven glioblastoma invasion study.

Caption

Open micro-valley chip for viscosity-driven glioblastoma invasion study. Schematic illustration of an open two-layer microfluidic membrane platform for investigating glioblastoma (GBM) cell invasion under viscous microenvironment conditions. The device features a detachable cap for controlled migration onset and a ring-shaped micropillar array that provides localized mechanical confinement, inducing nuclear deformation and YAP mechanotransduction activation. Long-term culture in high-viscosity medium (7.1 cP) mimicking the GBM invasive periphery drives cell-type-dependent adaptive responses, enabling real-time visualization of viscosity-induced phenotypic transitions in tumor cell motility and invasive potential.

Credit

Microsystems & Nanoengineering

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CC BY-NC-ND

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