An example of partial response. 58-year-old patient with neuroendocrine neoplasm of the pancreas with hepatic and bone metastases. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

An example of partial response. 58-year-old patient with neuroendocrine neoplasm of the pancreas with hepatic and bone metastases.

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Figure 1. An example of partial response. 58-year-old patient with neuroendocrine neoplasm of the pancreas with hepatic and bone metastases. Previously treated with chemotherapy, hemithyroidectomy, PRRT with 177Lu-DOTATATE, Lanreotide, Everolimus, trans-arterial chemo-embolization of liver metastases. After 2 cycles of TANDEM DOTA-LM3 PRRT, she achieved partial remission of disease (reduced hepatic and bone metastases). PRRT resulted in improved quality of life including reduced abdominal pain and enhanced physical activity. Delayed side effects include anemia G2 and reduced platelets count G3. A) 68Ga-DOTA-LM3 PET/CT scan pre-PRRT in July 2023. B) 68Ga-DOTA-LM3 PET/CT scan post-PRRT (1x TANDEM DOTA-LM3 PRRT with 225AC and 177Lu) in September 2023. C) PET/CT images (from left to right) pre-PRRT in July 2023, post-first cycle of TANDEM PRRT in September 2023, and post-second cycle of TANDEM PRRT (November 2023). The images show the reduced uptake and dimension of the tumoral lesions.

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