LRH-1 shows an up-regulated expression in CRPC xenograft and cell models (IMAGE)

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LRH-1 shows an up-regulated expression in CRPC xenograft and cell models

Caption

(A) Expression profile of LRH-1 in the VCaP-CRPC xenograft model as revealed from a GEO dataset (GSE31410). (B) Expression profile of LRH-1 in a patient-derived xenograft (PDX) model of PCa as revealed from a GEO dataset (GSE59986). (C) Expression profile of LRH-1 in CRPC PCa cells after long-term anti-androgen treatment (enzalutamide treatment). (D) Endogenous expression of LRH-1 in various PCa cell lines. (E, F) Immunoblots and the relative protein expression levels of LRH-1, AR and PSA in TM00298-CRPC PDX model. (G, H) Immunoblot analysis revealed that LRH-1 displays significantly higher protein levels in the LNCaP-derived androgen-independent cell subline LNCaP-AI than in the parental LNCaP cells. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗∗P < 0.0001.

Credit

Wenxing You, Tiantian Gao, Haolong Li, Daniel Hau Tak Lam, Wenjuan Xie, Lijia Xiao, Weijie Gao, Dinglan Wu, Junjian Wang, Yuliang Wang, Franky Leung Chan

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