Rethinking oral antibiotics after pediatric appendicitis. (IMAGE)

Zhejiang University

Rethinking oral antibiotics after pediatric appendicitis.

Caption

Rethinking oral antibiotics after pediatric appendicitis. This graphical summary shows the study design and key findings of a systematic review and meta-analysis on post-discharge oral home antibiotics (OHA) in children with complicated acute appendicitis (CAA). Across 14 observational studies, OHA did not show consistent benefits in reducing intra-abdominal abscesses, organ/space infections, or readmissions, while exposure-restricted analysis suggested a possible increase in readmission risk. The evidence was rated as very low certainty, highlighting the need for high-quality multicenter randomized controlled trials (RCTs) to clarify whether routine OHA after discharge is necessary.

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World Journal of Pediatrics

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