A copper-related pathway connects trace element imbalance, myelin development, and social behavior (IMAGE)
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A schematic overview of the study. In individuals with autism spectrum disorder, lower plasma copper levels were associated with clinical symptom scores, whereas reduced white matter volume was associated with social symptom scores. In a mouse model, developmental copper deficiency impaired myelination and altered social behavior, accompanied by changes in mitochondrial regulation and mTOR signaling.
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Niigata University
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