Figure 2. Proposed mechanisms of oxime-containing compound lethality. (IMAGE)

Science Exploration Press

Figure 2. Proposed mechanisms of oxime-containing compound lethality.

Caption

Proposed mechanisms of oxime-containing compound lethality. (A) A visual map of enzymes and metabolites in the mevalonate and cholesterol synthesis pathways that have been implicated in ferroptosis; (B) A simplified map of core lipid metabolic components essential to the execution of lipid-dependent necrosis induced by the oxime-containing lethal compounds CIL56 and tegavivint. CoA: coenzyme A; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A; IPP: isopentenyl pyrophosphate; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase; FPP:farnesyl pyrophosphate; GGPP: geranylgeranyl diphosphate; CoQ10: coenzyme Q10; SQS: squalene synthase; ER: endoplasmic reticulum; 7-DHC: 7-dehydrocholesterol; ACC1: acetyl-CoA carboxylase 1; TOFA: 5-(tetradeclyoxy)-2-furoic acid; 2-BP: 2-bromopalmitate; ZDHHCs: zinc finger DHHC domain-containing palmitoyl S-acyltransferases; TECR: trans-2,3-enoyl-CoA reductase.

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© Scott J. Dixon*, et al. 2026. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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