Schematic illustration of nanomedicine-mediated mitochondrial repair for neuroinflammation suppression (IMAGE)

Science China Press

Schematic illustration of nanomedicine-mediated mitochondrial repair for neuroinflammation suppression

Caption

Well-designed nanomedicines cross the blood–brain barrier (BBB), target damaged mitochondria in neurovascular unit (NVU) cells, and suppress neuroinflammation in central nervous system (CNS) diseases. They reduce mitochondrial reactive oxygen species (ROS), prevent calcium overload and mitochondrial permeability transition pore (mPTP) opening, support mitochondrial transport, regulate quality control, and address other dysfunction mechanisms. By repairing mitochondria in neurons, microglia, astrocytes, brain microvascular endothelial cells (BMECs), and pericytes, these nanomedicines safely and precisely control neuroinflammation, reducing neuronal damage, inhibiting glial activation, preventing inflammatory storms, and protecting BBB integrity to limit immune infiltration and halt the spread of inflammation.

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