Overview of the evolution of CAR structures (IMAGE)
Caption
A schematic representation of the progressive development of CAR-T cell generations from first to fourth, highlighting enhancements such as improved co-stimulatory domains, cytokine production capabilities, and multi-antigen targeting to overcome the limitations encountered in earlier versions. CAR = chimeric antigen receptor, scFv = single-chain variable fragment.
Credit
Grace El Bejjani from Lebanese American University, Lebanon Image source link: https://journals.lww.com/jpancreatology/fulltext/2026/03000/role_of_car_t_cell_therapy_in_pancreatic_cancer_.1.aspx
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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND