Huntington Disease Key Immune Pathway (IMAGE)

Florida Atlantic University

Huntington Disease Key Immune Pathway

Caption

Researchers identified the immune cGAS-STING pathway as a key contributor to harmful inflammation. Using a humanized mouse model of Huntington disease, they found that blocking this pathway – either by removing the cGAS gene or using a drug that inhibits STING – reduced brain inflammation, protected neurons and improved motor function.

Credit

Credit: Anuradha Kesharwani, Ph.D., FAU

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Credit: Anuradha Kesharwani, Ph.D., FAU

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