The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation (IMAGE)
Caption
Figure 10: Biochemical effects of PCAIs on cancer cells.
PCAIs-treated cancer cells show the depletion of the monomeric G-proteins RAC1 and RHOA. MAPK and PI3K/AKT signaling pathways are activated resulting in the generation of ROS, caspases activation and apoptosis. Actin filaments and its dependent processes were also suppressed resulting in cell rounding and possibly anoikis. Key genes that impact cell survival and cancer progression were either upregulated or downregulated upon PCAIs treatment.
Credit
Copyright: © 2026 Ofosu-Asante et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Usage Restrictions
With credit to the original source.
License
Original content