Butyrate Enhances Dendritic Cell Development Through Epigenetic Regulation (IMAGE)
Caption
Researchers found that butyrate, a short-chain fatty acid produced by gut bacteria during the fermentation of dietary fiber, promotes dendritic cell development by inhibiting histone deacetylases and increasing histone acetylation. This epigenetic regulation enhances the expression of the Spi1 gene encoding the transcription factor PU.1 and the Itga4 gene encoding the α4 subunit of LPAM-1, leading to increased expression of dendritic cell-related genes and surface molecules. The findings reveal a molecular link between dietary fiber-derived microbial metabolites and immune-cell regulation.
Credit
Professor Chiharu Nishiyama from Tokyo University of Science (TUS), Japan Image link: https://doi.org/10.1016/j.alit.2026.05.005
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