Folate and methionine cycle (IMAGE)

Ben-Gurion University of the Negev

Folate and methionine cycle

Caption

Schematic representation of the folate and methionine cycle, illustrating key enzymes and metabolites involved in one-carbon metabolism and genotype-related differences in folate metabolism (created with BioRender.com). DHFR, dihydrofolate reductase; DHF, dihydrofolate; THF, tetrahydrofolate; MTHFR, methylenetetrahydrofolate reductase; MTHFD1, methylenetetrahydrofolate dehydrogenase 1; MTHFD2, methylenetetrahydrofolate dehydrogenase 2; MTR, methionine synthase; MTRR, methionine synthase reductase; hCys, homocysteine; CBS, cystathionine-β-synthase; Cys, cysteine; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine.

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Prof. Iris Shai

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