GALNT7-mediated O-GalNAc glycosylation stabilizes KIT, activates PI3K/AKT and MAPK/ERK signaling, and drives malignant progression of gastrointestinal stromal tumor (GIST); benzyl-α-GalNAc suppresses this axis. (IMAGE)

West China Hospital of Sichuan University

GALNT7-mediated O-GalNAc glycosylation stabilizes KIT, activates PI3K/AKT and MAPK/ERK signaling, and drives malignant progression of gastrointestinal stromal tumor (GIST); benzyl-α-GalNAc suppresses this axis.

Caption

GALNT7-mediated O-GalNAc glycosylation stabilizes KIT, activates PI3K/AKT and MAPK/ERK signaling, and drives malignant progression of gastrointestinal stromal tumor (GIST); benzyl-α-GalNAc suppresses this axis.

Credit

Precision Clinical Medicine

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