Schematics of the customized lensfree holography system and the digital HER2 classification model (IMAGE)

BMEF (BME Frontiers)

Schematics of the customized lensfree holography system and the digital HER2 classification model

Caption

(A) Photo of the lensfree holography system. (B) Physical and digital workflow of the automated HER2 scoring system using lensfree holography. (C) Visualization of the whole-slide lensfree holographic image from a HER2 IHC-stained sample slide. (D) Zoomed-in FOV of the lensfree hologram. Sub-pixel-level spatial registration between the illumination color channels is not required, as the downstream deep learning models are designed to be robust to spatial misalignments across the RGB illumination channels; hence, rainbow artifacts are observed in each tissue core.

Credit

Ozcan Lab@UCLA.

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