Smart pH-responsive nanoplatform accelerates healing of infected wounds (IMAGE)
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Schematic illustration of the therapeutic mechanism of SH@ZIF-8/AgNPs in infected wounds. In the acidic microenvironment of infected tissue, the nanoplatform gradually degrades and releases silver ions and shikonin. The released agents inhibit bacterial growth, scavenge excessive reactive oxygen species (ROS), reduce inflammation, and promote angiogenesis, collagen deposition, and tissue regeneration.
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Yanjun Li, Songsong Huang & Shaopeng Wang
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