HIF-2a inhibition with casdatifan (IMAGE)

Arcus Biosciences Inc

HIF-2a inhibition with casdatifan

Caption

Composite image depicting HIF-2α inhibition with casdatifan within the renal cell carcinoma microenvironment. The yellow small molecule represents Casdatifan bound within the HIF-2α PAS-B pocket, disrupting HIF-2α/ARNT-dependent hypoxia signaling. The multiplex tissue background illustrates the complex RCC ecosystem, including malignant epithelial cells, stromal and vascular architecture, and immune-cell infiltrates

Credit

Arcus Biosciences

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