Alterations of the Nigrostriatal Dopaminergic System after Parkinson’s Disease Modeling in Il6 Knockout (KO) and Wild-Type (WT) Mice of both Sexes (IMAGE)
Caption
(A–D) TH protein levels in the striatum of female mice (A, B) and male mice (C, D) at 3 days post-MPTP administration. β-actin served as the loading control. n = 3–5. (E–H) Density of TH-positive nerve fibers in the striatum of female mice (E, G) at 3 days post-MPTP administration (n = 4 or 5) and male mice (F, H) at 7 days post-MPTP administration (n = 5). Scale bar: 200 μm and 50 μm (zoom). (I–L) Counting of TH-positive cells in the SNpc of female mice (I, K) at 3 days post-MPTP administration (n = 4 or 5) and male mice (J, L) at 1 day, 3 days, and 7 days post-MPTP administration (n = 4 or 5). Scale bar: 200 μm. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗∗P < 0.0001.
Credit
Fangzheng Chen, Yufei Duan, Mengze Wang, Zhaolin Liu, Jiayin Zhao, Guangchun Fan, Yongtao He, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Xin Yan, Chenye Shen, Xiwen Tang, Yuanyuan Ma, Mei Yu, Renyuan Zhou, Jian Fei, Fang Huang.
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