Transcriptomic profiling reveals key insights into the formation of vasculogenic mimicry (VM) in oral squamous cell carcinoma (OSCC) (IMAGE)
Caption
(A) Workflow of sample collection, processing, and analysis for transcriptome. The diagram was created with BioGDP.com. (B) Scatter plot of principal components (PCs) based on gene expression profiles. (C, D) Mfuzz algorithm-based different dynamic transcript expression patterns during VM formation in OSCC. (E) Functional annotation of gene cluster C1 and C2 using GO and KEGG enrichment analysis. (F) GSEA plot showing the associations of VM status with Toll-like receptor signaling pathway, TNF-alpha signaling via NF-κB, cytokine–cytokine receptor interaction, and VM-related gene signatures. (G) Barplot of GSVA showing the different activation states of hallmark gene sets related to the VM formation in OSCC. ns, no statistical significance; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001. Scale bar, 50 μm.
Credit
Wendong Wan, Liwei Ma, Wenjin Wang, Jianjun Wu, Chengxin Shi, Xuancheng Hui, Muhammad Tufail, Cheng Guo, Canhua Jiang, Lunquan Sun, Ning Li, Xing Gao
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