Tunable C–H functionalization of phosphonates. (a) C–H functionalization of aryl phosphonates. (b) C–H functionalization of benzyl phosphonates. (c) Bifunctional ligand-controlled tunable meta- and para-C–H borylation of aryl and benzyl phosphonat (IMAGE)

Shanghai Jiao Tong University Journal Center

Tunable C–H functionalization of phosphonates. (a) C–H functionalization of aryl phosphonates. (b) C–H functionalization of benzyl phosphonates. (c) Bifunctional ligand-controlled tunable meta- and para-C–H borylation of aryl and benzyl phosphonat

Caption

  • Previous studies mainly enabled ortho functionalization of phosphonates, while remote meta and para selectivity remained challenging.
  • Two bifunctional ligand families control regioselectivity through noncovalent interactions with phosphoryl groups. L1/L3 direct meta-selective borylation, whereas L5/L8 promote para selectivity.
  • The strategy applies to both aryl and benzyl phosphonates, providing tunable meta and para C–H borylation with up to 98:2 regioselectivity under mild conditions.

Credit

Han Ang, Yajun Wang, Jiawei Ma, Shengmeng Qin, Shuo Lu, Wenju Chang, and Yong Liang.

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