STUB1–SIRT6–NRF2 signaling protects neurons after spinal cord injury. (IMAGE)

Burns & Trauma

STUB1–SIRT6–NRF2 signaling protects neurons after spinal cord injury.

Caption

STUB1–SIRT6–NRF2 signaling protects neurons after spinal cord injury.
Following spinal cord injury, STUB1 stabilizes SIRT6 through lysine 63 (K63)-linked ubiquitination, preventing its proteasomal degradation. Stabilized SIRT6 deacetylates nuclear factor erythroid 2-related factor 2 (NRF2), promotes its nuclear translocation and activates antioxidant defenses, thereby reducing neuronal ferroptosis and supporting functional recovery.

Credit

Burns & Trauma

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