How Do Tumor Cells “Rewrite Their Identity”? Precision Omics Reveals a New Route of Head and Neck Squamous Cell Carcinoma Metastasis (IMAGE)

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How Do Tumor Cells “Rewrite Their Identity”? Precision Omics Reveals a New Route of Head and Neck Squamous Cell Carcinoma Metastasis

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Head and neck squamous cell carcinoma often progresses through metastasis, yet its cellular basis remains unclear. This study maps the pan-metastatic landscape of HNSCC and identifies a WDR54-driven cell identity reshaping axis. WDR54 epigenetically activates TGF-β-mediated pEMT, enhancing invasion, immune evasion and metastatic potential, offering new insight into prognosis and precision therapy.

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