Figure. Mechanistic model of C/EBPγ-mediated EMT, DNA repair, and therapy resistance in lung adenocarcinoma (IMAGE)

Kanazawa University

Figure. Mechanistic model of C/EBPγ-mediated EMT, DNA repair, and therapy resistance in lung adenocarcinoma

Caption

Figure. Mechanistic model of C/EBPγ-mediated EMT, DNA repair, and therapy resistance in lung adenocarcinoma
Proposed model illustrating how C/EBPγ promotes epithelial-mesenchymal transition (EMT) through antagonism of C/EBPβ while enhancing DNA double-strand break repair through interactions with XRCC5/XRCC6. These dual functions increase survival of lung adenocarcinoma cells under genotoxic stress and may contribute to therapy resistance.

Credit

Terashima M. et al., Cell Death Discovery (2026), Figure 7F

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