Environmental eustress inhibits CCL2 to overcome doxorubicin-induced cardiotoxicity and alleviate tumor growth (IMAGE)
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This study focuses on the clinical challenge of doxorubicin-induced cardiotoxicity and explores the potential of eustress as a non-pharmacological intervention that simultaneously alleviates cardiac damage and enhances anti-tumor efficacy.
This study proposes for the first time the concept of a "hypothalamus-heart-tumor axis," systematically revealing the dual effects of eustress—cardioprotection and chemotherapy sensitization—in the setting of chemotherapy-induced cardiotoxicity coexisting with tumors. It establishes Ccl2 as a core intervention target in cardio-oncology. These findings not only expand the understanding of psychological and emotional factors in disease regulation but also provide a safe, accessible, non-pharmacological intervention strategy for managing chemotherapy-related cardiotoxicity in cancer patients, with significant theoretical implications and translational potential.
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