Delayed growth of SK-ES-1 Ewing sarcoma tumor xenografts is associated with reduced Trk and IGF1R pathway markers (IMAGE)
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Figure 6: Schematic model highlighting selected aspects of K252a effects on ES.
Systemic administration of K252a transiently delays the growth of human SK-ES-1 ES tumors xenografted into nude mice and reduces expression and phosphorylation of TrkA, TrkB, PI3K, and IGF1R in the tumors. Combined exposure to K252a and the IGF1R inhibitor NVP-ADW742 reduces SK-ES-1 ES cell viability more effectively than each compound alone.
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